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The dose
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& Prescott, R
Most patients notice weight loss within 4 to 8 weeks of starting semaglutide, according to the STEP 1 trial
Important pharmacologic and practical differences Route and formulation / absorption issues Since semaglutide is a peptide, it can be broken down in the stomach by proteolytic enzymes, which limits its natural bioavailability
This means it can raise blood levels of statins (increasing the risk of muscle damage and cardiac toxicity), blood thinners like warfarin, certain diabetes medications like sulfonylureas, and immunosuppressants like cyclosporine
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